Dihydropyridine

Dihydropyridine

Skeletal formula of dihydropyridine Ball-and-stick model of the dihydropyridine molecule
Names
Systematic IUPAC name 1,4-Dihydropyridine
Identifiers
CAS Number	3337-17-5 Y
ChemSpider	94619 Y
Jmol 3D model	Interactive image
MeSH	1,4-dihydropyridine
PubChem	104822
InChI InChI=1S/C5H7N/c1-2-4-6-5-3-1/h2-6H,1H2 Y Key: YNGDWRXWKFWCJY-UHFFFAOYSA-N Y
SMILES C1C=CNC=C1
Properties
Chemical formula	C 5H 7N
Molar mass	81.1158 g mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Dihydropyridine is a molecule based upon pyridine, and the parent of a class of molecules that have been semi-saturated with two substituents replacing one double bond. They are particularly well known in pharmacology as L-type calcium channel blockers, used in the treatment of hypertension. Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, they are relatively vascular selective in their mechanism of action in lowering blood pressure.

Class members

Dihydropyridine class L-type calcium channel blockers include, in alphabetical order (brand names vary in different countries):

Name	Image	Brand name
Amlodipine		Norvasc, Istin, Normodipine, Tenox, Cordi Cor
Aranidipine	175px	Sapresta (サプレスタ)
Azelnidipine	250px	CalBlock (カルブロック)
Barnidipine		Vasexten, Libradin, Cyress, HypoCa
Benidipine		Coniel
Cilnidipine	265px	Atelec (アテレック), Cilacar, Cinalong, Siscard
Clevidipine		Cleviprex
Cronidipine	250px
Darodipine
Dexniguldipine	300px
Efonidipine		Landel (ランデル)
Elgodipine	270px
Elnadipine	160px
Felodipine		Renedil, Plendil
Flordipine	175px
Furnidipine	215px
Iganidipine	275px
Isradipine	165px	DynaCirc CR
Lacidipine	200px	Lacipil, Motens, Sakure
Lemildipine	180px
Lercanidipine		Zanidip, Zanidip-Recordati
Levamlodipine	175px	EsCordi Cor
Levniguldipine	300px
Manidipine		Manyper, Caslot, Madipine
Nicardipine		Cardene, Cardene SR
Nifedipine		Adalat, Nifedical, Procardia, Corinfar, Cordaflex
Niguldipine
Niludipine	300px
Nilvadipine		Nivadil
Nimodipine		Nimotop
Nisoldipine		Sular, Baymycard, Syscor
Nitrendipine		Baypress, Cardif, Nitrepin, Baylotensin
Olradipine	250px
Oxodipine
Palonidipine	300px
Pranidipine	250px	Acalas
Ryodipine
Sagandipine	260px
Sornidipine	225px
Teludipine	220px
Tiamdipine	215px
Trombodipine	280px
Vatanidipine	315px

The pharmaceutical drug finerenone is also a dihydrophyridine derivative, but does not act as a calcium channel blocker but as an antimineralocorticoid.

See also

• Calcium channel blocker
• Calcium channel
• Dihydropyridine receptor

External links

• Dihydropyridines at the US National Library of Medicine Medical Subject Headings (MeSH)