File:Triad mechanism.svg
Summary
General reaction mechanism of catalysed by a catalytic triad (black): <a href="//commons.wikimedia.org/w/index.php?title=Nucleophilic_substitution&action=edit&redlink=1" class="new" title="Nucleophilic substitution (page does not exist)">nucleophilic substitution</a> at a <a href="//commons.wikimedia.org/w/index.php?title=Carbonyl&action=edit&redlink=1" class="new" title="Carbonyl (page does not exist)">carbonyl</a> substrate (red) by a second substrate (blue). First, the enzyme's nucleophile (X) attacks the carbonyl to form a covalently linked acyl-enzyme intermediate. This intermediate is then attacked by the second nucleophile (X') of the second substrate. If the second nucleophile is the hydroxyl of water, the result is <a href="//commons.wikimedia.org/w/index.php?title=Hydrolysis&action=edit&redlink=1" class="new" title="Hydrolysis (page does not exist)">hydrolysis</a>, otherwise the result is <a href="//commons.wikimedia.org/w/index.php?title=Transferase&action=edit&redlink=1" class="new" title="Transferase (page does not exist)">group transfer</a> of X'.
Licensing
Lua error in package.lua at line 80: module 'strict' not found.
File history
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 21:16, 12 January 2017 | | 1,225 × 221 (225 KB) | 127.0.0.1 (talk) | General reaction mechanism of catalysed by a catalytic triad (black): <a href="//commons.wikimedia.org/w/index.php?title=Nucleophilic_substitution&action=edit&redlink=1" class="new" title="Nucleophilic substitution (page does not exist)">nucleophilic substitution</a> at a <a href="//commons.wikimedia.org/w/index.php?title=Carbonyl&action=edit&redlink=1" class="new" title="Carbonyl (page does not exist)">carbonyl</a> substrate (red) by a second substrate (blue). First, the enzyme's nucleophile (X) attacks the carbonyl to form a covalently linked acyl-enzyme intermediate. This intermediate is then attacked by the second nucleophile (X') of the second substrate. If the second nucleophile is the hydroxyl of water, the result is <a href="//commons.wikimedia.org/w/index.php?title=Hydrolysis&action=edit&redlink=1" class="new" title="Hydrolysis (page does not exist)">hydrolysis</a>, otherwise the result is <a href="//commons.wikimedia.org/w/index.php?title=Transferase&action=edit&redlink=1" class="new" title="Transferase (page does not exist)">group transfer</a> of X'. |
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