ATP11B

ATPase, class VI, type 11B
Identifiers
Symbols	ATP11B ; ATPIF; ATPIR
External IDs	OMIM: 605869 MGI: 1923545 HomoloGene: 32919 GeneCards: ATP11B Gene
EC number	3.6.3.1
Gene ontology Molecular function • magnesium ion binding • phospholipid-translocating ATPase activity • protein binding • ATP binding • ion transmembrane transporter activity Cellular component • nuclear inner membrane • early endosome • endoplasmic reticulum • Golgi apparatus • plasma membrane • membrane • integral component of membrane • recycling endosome • recycling endosome membrane Biological process • ion transport • metabolic process • aminophospholipid transport • ion transmembrane transport • phospholipid translocation • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23200	76295
Ensembl	ENSG00000058063	ENSMUSG00000037400
UniProt	Q9Y2G3	Q6DFW5
RefSeq (mRNA)	NM_014616	NM_029570
RefSeq (protein)	NP_055431	NP_083846
Location (UCSC)	Chr 3: 182.79 – 182.92 Mb	Chr 3: 35.75 – 35.86 Mb
PubMed search	[1]	[2]

Probable phospholipid-transporting ATPase IF is an enzyme that in humans is encoded by the ATP11B gene.

Function

P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.