Caspase 10
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene.[1]
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.[2]
Interactions
Caspase 10 has been shown to interact with FADD,[3][4][5][6] CFLAR,[5][7][8] Caspase 8,[3][7][9][10] Fas receptor,[3][4][11] RYBP,[12] TNFRSF1A[3][4] and TNFRSF10B.[3][11]
See also
References
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Further reading
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External links
- GeneReviews/NCBI/NIH/UW entry on Autoimmune Lymphoproliferative Syndrome
- The MEROPS online database for peptidases and their inhibitors: C14.011
