Chlornaphazine

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Chlornaphazine
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Names
IUPAC name
N,N-Bis(2-chloroethyl)naphthalen-2-amine
Other names
Chlornapazine; 2-Naphthylbis(chloroethyl)amine
Identifiers
494-03-1
ChEMBL ChEMBL2107519
ChemSpider 9885
Jmol 3D model Interactive image
KEGG C16446 YesY
PubChem 10307
UNII U46E473275 YesY
  • InChI=1/C14H15Cl2N/c15-7-9-17(10-8-16)14-6-5-12-3-1-2-4-13(12)11-14/h1-6,11H,7-10H2
    Key: XCDXSSFOJZZGQC-UHFFFAOYAW
  • ClCCN(c2ccc1c(cccc1)c2)CCCl
Properties
C14H15Cl2N
Molar mass 268.18 g·mol−1
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Chlornaphazine, a derivative of 2-naphthylamine, is a nitrogen mustard that was developed in the 1950s for the treatment of polycythemia and Hodgkin's disease.[1] However, a high incidence of bladder cancers in patients receiving treatment with chlornaphthazine led to use of the drug being discontinued.[2]

The International Agency for Research on Cancer has listed chlornaphazine as a human carcinogen.[3]

References

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  3. N,N-Bis(2-Chloroethyl)-2-Naphthylamine (Chlornaphazine), International Agency for Research on Cancer