Collagen, type XXV, alpha 1

Collagen, type XXV, alpha 1
Identifiers
Symbols	COL25A1 ; AMY; CFEOM5; CLAC; CLAC-P; CLACP
External IDs	OMIM: 610004 MGI: 1924268 HomoloGene: 57111 GeneCards: COL25A1 Gene
Gene ontology Molecular function • beta-amyloid binding • heparin binding Cellular component • extracellular region • collagen trimer • extracellular space • endoplasmic reticulum lumen • plasma membrane • integral component of plasma membrane • integral component of membrane Biological process • extracellular matrix disassembly • extracellular matrix organization • collagen catabolic process • axonogenesis involved in innervation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84570	77018
Ensembl	ENSG00000188517	ENSMUSG00000058897
UniProt	Q9BXS0	Q99MQ5
RefSeq (mRNA)	NM_001256074	NM_001244952
RefSeq (protein)	NP_001243003	NP_001231881
Location (UCSC)	Chr 4: 108.81 – 109.3 Mb	Chr 3: 130.13 – 130.6 Mb
PubMed search	[1]	[2]

Collagen alpha-1(XXV) chain is a protein that in humans is encoded by the COL25A1 gene.

COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease (AD; MIM 104300) brains (Osada et al., 2005).[supplied by OMIM]

Interactions

Collagen, type XXV, alpha 1 has been shown to interact with Amyloid precursor protein.