D-amino acid oxidase
| D-amino-acid oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| File:Crystal structure of RgDAAO (PDB code 1c0p).png
3D structure of DAAO from yeast (monomer)
|
|||||||||
| Identifiers | |||||||||
| EC number | 1.4.3.3 | ||||||||
| CAS number | Template:CAS | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
|
|||||||||
| D-amino-acid oxidase | |
|---|---|
| Identifiers | |
| Symbol | DAO (DAAO) |
| Entrez | 1610 |
| HUGO | 2671 |
| OMIM | 124050 |
| RefSeq | NM_001917 |
| UniProt | P14920 |
| Other data | |
| EC number | 1.4.3.3 |
| Locus | Chr. 12 q24 |
D-amino acid oxidase (DAAO; also DAO, OXDA, DAMOX) is a peroxisomal enzyme containing FAD as cofactor that is expressed in a wide range of species from yeasts to human.[1] It is not present in plants or in bacteria which instead use D-amino acid dehydrogenase. Its function is to oxidize D-amino acids to the corresponding imino acids, producing ammonia and hydrogen peroxide.
This enzyme belongs to the FAD dependent oxidoreductase family, and acts on the CH-NH2 group of D-amino acid donors with oxygen as acceptor. The enzyme is most active toward neutral D-amino acids, and not active toward acidic D-amino acids.
Recently, mammalian D-amino acid oxidase has been connected to the brain D-serine metabolism and to the regulation of the glutamatergic neurotransmission. In a postmortem study, the activity of DAAO was found to be two-fold higher in schizophrenia.[2]
DAAO is a candidate susceptibility gene[3] and together with G72 may play a role in the glutamatergic mechanisms of schizophrenia.[4] Risperidone and sodium benzoate are inhibitors of DAAO.
DAAO is used as a biocatalyst in several biotechnological applications, such as the oxidation of cephalosporin C, the deracemition of racemic D-amino acid solutions and as the biological component in several biosensors for the determination of the content in D-amino acids of biological fluids.
This protein may use the morpheein model of allosteric regulation. [5]
See also
External links
- D-Amino-Acid Oxidase at the US National Library of Medicine Medical Subject Headings (MeSH)
- http://www.calzyme.com/commerce/catalog/spcategory.jsp?category_id=1043
References
<templatestyles src="Reflist/styles.css" />
Cite error: Invalid <references> tag; parameter "group" is allowed only.
<references />, or <references group="..." />
<templatestyles src="Asbox/styles.css"></templatestyles>
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Gene Overview of All Published Schizophrenia-Association Studies for DAAO - SZGene database.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
.png){kind=link}