DGKB

Diacylglycerol kinase, beta 90kDa
Identifiers
Symbols	DGKB ; DAGK2; DGK; DGK-BETA
External IDs	OMIM: 604070 MGI: 2442474 HomoloGene: 37875 GeneCards: DGKB Gene
EC number	2.7.1.107
Gene ontology Molecular function • diacylglycerol kinase activity • calcium ion binding • ATP binding Cellular component • cytoplasm • plasma membrane Biological process • protein kinase C-activating G-protein coupled receptor signaling pathway • blood coagulation • phosphorylation • platelet activation • intracellular signal transduction Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE DGKB 216307 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1607	217480
Ensembl	ENSG00000136267	ENSMUSG00000036095
UniProt	Q9Y6T7	Q6NS52
RefSeq (mRNA)	NM_004080	NM_178681
RefSeq (protein)	NP_004071	NP_848796
Location (UCSC)	Chr 7: 14.15 – 14.97 Mb	Chr 12: 37.88 – 38.63 Mb
PubMed search	[1]	[2]

Diacylglycerol kinase beta is an enzyme that in humans is encoded by the DGKB gene.

Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene.