Embryo donation

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Embryo donation is a form of third party reproduction. It is defined as the giving—generally without compensation—of embryos remaining after one couple's in vitro fertilisation to either another person or couple for implantation or to research. Where it is given for the purpose of implantation, the donation is followed by the placement of those embryos into the recipient woman's uterus to facilitate pregnancy and childbirth in the recipient. The resulting child is considered the child of the woman who carries it and gives birth, and not the child of the donor. This is the same principle as is followed in egg donation or sperm donation. Most often, the embryos are donated after the woman for whom they were originally created has successfully carried one or more pregnancies to term.

For implantation

Embryo donation can be handled on an anonymous basis (donor and recipient parties are not known to each other), or on an open basis (parties' identities are shared and the families agree to a relationship). Occasionally, a "semi-open" arrangement is used in which the parties know family and other information about each other, but their real names and locating information are withheld, in order to provide a layer of privacy protection.

Embryo donation or adoption

Some writers use the term "embryo donation" to refer strictly to anonymous embryo donation, and "embryo adoption" to refer to the open process.[1] Others use the terms synonymously because regardless of whether the arrangement is open or anonymous, the donation of embryos and a clinical assisted reproduction procedure is involved, and the recipient couple is preparing to raise a child not genetically related to them.[2] Lawyers who assist couples who are trying to acquire an embryo state the term "embryo adoption" is a misnomer because the transfer of an embryo is handled as property transfer.[3][4][5] Abortion rights advocates, advocates of embryonic stem cell research, and members of the fertility industry object to referring to the transfer as an "adoption" because they feel it gives an embryo the same status as a child.[6] Most doctors describe the process as "embryo donation".[7]

Donor options

According to a survey by the American Society for Reproductive Medicine, 54% of fertility patients want to preserve their remaining embryos for future use.[8] Another 21% want to donate leftover embryos for research.[8] Donating embryos for research may be a good alternative when patients receive proper, honest and clear information about the research project, the procedures and the scientific value of the research.[9] The remaining 7% of those surveyed are willing to donate leftover embryos to another couple.[8]

Dr. Jeffrey Nelson is Director of the Huntington Reproductive Center, one of California's largest IVF clinics. He reports that "Twenty-five per cent of patients want to donate their [spare] embryos – not as many as I'd like." He added, "People tend to hold on to their embryos because they don't want to make a decision. We started buying more and more cryopreservation tanks, and we finally had to say that there's a fee for a certain number of years' storage, and beyond that the price starts to escalate."[10] It costs up to $1,200 a year to store frozen embryos.[11] As of May 2012, there were about 600,000 frozen embryos stored in laboratories and fertility clinics,[8] costing the donor families about $72 million annually for storage fees.[12]

Donor screening

In the United States, donors must, if possible, be screened for a series of infectious diseases.[13] The U.S. Food and Drug Administration (FDA) administers the rules for screening donors. If the donors are not available to be screened, the embryos must be given a label that indicates that the required screening has not been done, and the recipients must agree to accept the associated risk. The amount of screening the embryo has already undergone is largely dependent on the genetic parents' own IVF clinic and process. The embryo recipient may elect to have her own embryologist conduct further testing.

or donating them for use in embryonic stem cell research. Although embryos can, theoretically, survive indefinitely in frozen storage, as a practical reality someone must eventually decide on a permanent disposition for them.

A US study concluded that donating an embryo is approximately twice as cost-effective as oocyte donation in terms of cost per live birth, with a cost of $22,000 per live delivery compared to $41,000 for oocyte donation.

History

Soon after in vitro fertilization became a common clinical practice, clinicians discovered a way to preserve embryos in frozen storage and thaw them for implantation later. This procedure can spare a woman donor from a second egg harvesting procedure.[14][15]

At about the same time, clinicians reasoned that more couples could be helped toward parenthood by substituting donor sperm for men who have no viable sperm, or donor eggs for women who have no viable oocytes – or both. Thus what was called gamete and embryo donation, came into being. A careful reading of the 1983 clinical report often cited as the first instance of embryo donation reveals that the donated embryo was actually created for the recipient at the same time that four embryos were made for the donor couple's own use. The menstrual cycles of the donor and recipient women were synchronized using medications, and the transfers occurred on the same day. None of these embryos had been cryopreserved.[citation needed]

Soon thereafter, reports were published documenting successful pregnancies and births from cryopreserved donor embryos. Again, however, these were embryos made from donor gametes specifically for the recipients.[16][17]

No one knows for sure when the first true embryo adoption occurred. The term was used as early as the mid-1980s,[18][19] in the legal literature. Devroey et al.,[20] Dr. Maria Bustillo in Florida, and Dr. Howard Jones in Virginia have reported embryo transfers occurring between 1986 and 1990 that clearly represented adoption of remaining embryos.

Prior to this, thousands of women who were infertile had regarded adoption as the only available path to parenthood. These scientific advances set the stage to allow open and candid discussion of embryo donation and transfer as a solution to infertility. In some ways, it is similar to other donations such as blood and major organ donations. Some see the embryo as "tissue", others see it as a "gift of a potential life",[21] while still others believe that a new human life begins at the time of fertilization. The third group sees embryo donation as little different from traditional adoption, except that the recipient woman has the experience of pregnancy and childbirth, and that no court action is required to establish legal parentage for the recipient.

The matter gained another political dimension in the United States when Congress and the Bush administration budgeted $1 million to promote embryo adoption.[22]

Process

Embryo donation is legally considered a property transfer and not an adoption by state laws. However, Georgia enacted a statute called the "Option of Adoption Act" in 2009 which provided a procedure for, but (importantly) did not require—a confirmatory court order of parentage following embryo adoption.[23] One advantage some embryo adoption couples in Georgia have derived from this law is that they have become eligible for the federal Adoption Tax Credit.

Embryo donation can be carried out as a service of an individual infertility clinic (where donor and recipient families typically live in the local area and are both patients of the same clinic) or by any of several national organizations. The process described below is typical of an "adoption-agency-based" national program.[citation needed]

Genetic parents entering an embryo adoption program are offered the benefits of selecting the adoptive parents from the agency's pool of prescreened applicants. Embryo ownership is transferred directly from the genetic parents to the adoptive parents. Genetic parents may be updated by the agency when a successful pregnancy is achieved and when a child(ren) is/are born. The genetic parents and adoptive parents may negotiate their own terms for future contact between the families.[citation needed]

Prospective adoptive parents entering a program complete an application, and may also complete a traditional adoption home study, fertility or adoption education, background and health checks and in some cases, depending on the requirements of both the home study and placement agencies, court certification of adoption eligibility. Their completed paperwork and fees are submitted to the placement agency, which reviews their file. Some agencies allow the donors to choose the recipient while others match the recipient parents with similar preferences including desired level of openness post-adoption. Genetic and prospective parents are then given the chance to approve the match. Once all parties agree, the embryo is transferred to the adoptive mother's clinic for a frozen embryo transfer.[citation needed]

None of the procedures involved with embryo adoption by either the genetic or adopting parents are legal requirements of embryo transfer. The process is entered into willingly by both sets of parents because of the added safeguards, knowledge and communication offered to both parties by the system.[24]

For research

Embryo donation to research provides a major source of stem cells for stem cell research. The hope is that stem cell research will aid in finding cures for various major diseases such as Alzheimer, cancer, SMA, and Parkinson's diseases. Some stem cell research is done by using human embryos, and one option that parents have once they are done with in vitro fertilization is to donate their unused embryos to stem cell research. One review came to the result that the proportion of IVF users who donated embryos for research varied geographically, from 7% in France to 73% in Switzerland.[25] A study done in the United States revealed that 60% of American donors would donate the unused embryos to science.[26]

People who donate embryos for research often have been found in a review to report feelings of reciprocity towards science and medicine, positive views of research and high levels of trust in the medical system. They have described the decision to donate as better than the destruction of embryos, and as an opportunity to help others or to improve health and IVF technology. On the other hand, reported factors that make people refrain from embryo donation to research include a perception of risks, a lack of information concerning research projects and the medical system, as well as conceptualization of embryos in terms of personhood. The influence of sociodemographic characteristics and reproductive and gynecological history have mainly been found to be inconclusive.[25]

See also

References

  1. ↑ Snowflake Program, Nightlight Christian Adoptions
  2. ↑ National Embryo Donation Center
  3. ↑ Charles P. Kindregan & Maureen McBrien, Assisted Reproductive Technology: A Lawyer's Guide to Emerging Law and Science 109-10 (2006).
  4. ↑ Rob Blackhurst, The pro-lifers adopting 'spare' embryos created during IVF, Telegraph (London), Oct. 8, 2013 (hereinafter cited as Blackhurst, Pro-lifers)
  5. ↑ Cheryl Wetzstein, Embryo adoption becoming the rage, Wash. Times, Apr. 19, 2009.
  6. ↑ Pam Belluck, From Stem Cell Opponents, an Embryo Crusade, N.Y. Times, June 2, 2005 (hereinafter cited as Belluck, Crusade).
  7. ↑ Jessie Beauchaine, The Next Frontier of the Stem Cell Debate:"Snowflake" babies, embryo "adoption," and being pre-born again, Village Voice, June 17, 2009.
  8. ↑ 8.0 8.1 8.2 8.3 Pamela Brown Controversial embryo adoptions on the rise May 1, 2012 WJLA.COM
  9. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  10. ↑ Blackhurst, Pro-lifers.
  11. ↑ Blackhurst, Pro-lifers
  12. ↑ Craig Young Funding cut threatens Loveland-based program that encourages adoption of frozen embryos; women tell adoption stories March 10, 2012 Loveland Reporter-Herald
  13. ↑ http://www.fda.gov/BiologicsBloodVaccines/TissueTissueProducts/QuestionsaboutTissues/ucm136397.htmhttp://www.miracleswaiting.org/explorembryo.html
  14. ↑ Trounson A, Freemann L. The use of embryo cryopreservation in human IVF programmes. Clin Obstet Gynaecol 1985 Dec;12(4):825-33
  15. ↑ Downing BG, Mohr LR, Trounson AO, Freemann LE, Wood C. Birth After Transfer of Cryopreserved Embryos. Med J Aust 1985 Apr 1;142(7):409-11
  16. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  17. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  18. ↑ Robertson JA. Embryos, Families, and Procreative Liberty: the Legal Structure of the New Reproduction. Southern California Law Review. 1986. 59: 939-1041
  19. ↑ Wurmbrand MJ. Frozen embryos: moral, social, and legal implications. South Calif Law Rev 1986 Jul;59(5):1079-1100
  20. ↑ Devroey P, Camus M, van den Abbeel E, van Waesberghe L, Wisanto A, van Steirteghem AC. Establishment of 22 Pregnancies After Oocyte and Embryo Donation. Br J Obstet Gynaecol 1989 Aug;96(8):900-906
  21. ↑ National Embryo Donation Center: Questionnaire Study of Prospective Embryo Donors
  22. ↑ The White House. President Discusses Stem Cell Research. Office of the Press Secretary, August 9, 2001. https://georgewbush-whitehouse.archives.gov/news/releases/2001/08/20010809-2.html
  23. ↑ http://www.gainesvilletimes.com/news/archive/20665/
  24. ↑ Embryo Adoption & Donation
  25. ↑ 25.0 25.1 Lua error in package.lua at line 80: module 'strict' not found.
  26. ↑ 60% of Donors Would Donate Unused Embryos for Stem Cell Research
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