GPVI

Glycoprotein VI (platelet)
250px PDB rendering based on 2gi7.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2GI7
Identifiers
Symbols	GP6 ; BDPLT11; GPIV; GPVI
External IDs	OMIM: 605546 MGI: 1889810 HomoloGene: 9488 GeneCards: GP6 Gene
Gene ontology Molecular function • receptor activity • transmembrane signaling receptor activity • protein binding • collagen binding Cellular component • plasma membrane • integral component of plasma membrane • cell surface • extracellular exosome • tetraspanin-enriched microdomain Biological process • enzyme linked receptor protein signaling pathway • blood coagulation • platelet activation • leukocyte migration Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE GP6 220336 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51206	243816
Ensembl	ENSG00000088053	ENSMUSG00000078810
UniProt	Q9HCN6	P0C191
RefSeq (mRNA)	NM_001083899	NM_001163014
RefSeq (protein)	NP_001077368	NP_001156486
Location (UCSC)	Chr 19: 55.01 – 55.04 Mb	Chr 7: 4.37 – 4.4 Mb
PubMed search	[1]	[2]

Glycoprotein VI (platelet) also known as GPVI is a glycoprotein receptor for collagen which is expressed in platelets. In humans, glycoprotein VI is encoded by the GPVI gene.

Function

Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke.

Complete or partial deficiency of GPVI in humans is a rare condition presenting as a mild bleeding disorder.

Interactions

GPVI has been shown to interact with LYN.

See also

• collagen receptor

External links

• GPVI protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)