Idalopirdine

Idalopirdine

Systematic (IUPAC) name
2-(6-Fluoro-1H-indol-3-yl)-N-(3-(2,2,3,3-tetrafluoropropoxy)benzyl)ethanamine
Identifiers
CAS Number	467459-31-0 N
ATC code	None
ChemSpider	19878969 N
ChEMBL	CHEMBL3286580
Synonyms	Lu-AE-58054
Chemical data
Formula	C20H19F5N2O
Molecular mass	398.37 g/mol
SMILES FC(F)C(F)(F)COc1cccc(c1)CNCCc3cnc2cc(F)ccc23
InChI InChI=1S/C20H19F5N2O/c21-15-4-5-17-14(11-27-18(17)9-15)6-7-26-10-13-2-1-3-16(8-13)28-12-20(24,25)19(22)23/h1-5,8-9,11,19,26-27H,6-7,10,12H2 N Key:YBAWYTYNMZWMMJ-UHFFFAOYSA-N N
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Idalopirdine (INN) (code names Lu AE58054, SGS-518) is a potent and selective 5-HT₆ receptor antagonist under development by Lundbeck as an augmentation therapy for the treatment of cognitive deficits associated with Alzheimer's disease and schizophrenia. As of October 2013 it is in phase III clinical trials.

See also

• Cerlapirdine
• Latrepirdine

External links

• Lundbeck expands its pipeline - initiating phase II clinical trials with a new compound for the treatment of schizophrenia
• Lundbeck initiates clinical phase II trials with Lu AE58054 as augmentation treatment in Alzheimer's disease