LILRB5

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5
Identifiers
Symbols	LILRB5 ; CD85C; LIR-8; LIR8
External IDs	OMIM: 604814 HomoloGene: 134027 GeneCards: LILRB5 Gene
Gene ontology Molecular function • transmembrane signaling receptor activity Cellular component • integral component of membrane Biological process • adaptive immune response • defense response • cell surface receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10990	n/a
Ensembl	ENSG00000105609	n/a
UniProt	O75023	n/a
RefSeq (mRNA)	NM_001081442	n/a
RefSeq (protein)	NP_001074911	n/a
Location (UCSC)	Chr 19: 54.25 – 54.26 Mb	n/a
PubMed search	[1]	n/a

Leukocyte immunoglobulin-like receptor subfamily B member 5 is a protein that in humans is encoded by the LILRB5 gene.

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene.