Neboglamine

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Neboglamine
Neboglamine.svg
Systematic (IUPAC) name
(4S)-4-Amino-5-[(4,4-dimethylcyclohexyl)amino]-5-oxopentanoic acid
Identifiers
CAS Number 163000-63-3
ATC code None
PubChem CID: 3074827
ChemSpider 2333649
Synonyms Nebostinel; N-(4,4-Dimethylcyclohexyl)-L-α-glutamine
Chemical data
Formula C13H24N2O3
Molecular mass 256.34126 g/mol
  • CC1(CCC(CC1)NC(=O)C(CCC(=O)O)N)C
  • InChI=1S/C13H24N2O3/c1-13(2)7-5-9(6-8-13)15-12(18)10(14)3-4-11(16)17/h9-10H,3-8,14H2,1-2H3,(H,15,18)(H,16,17)/t10-/m0/s1
  • Key:VCRGLZYPNNAVRP-JTQLQIEISA-N

Neboglamine (INN) (developmental code names CR-2249, XY-2401), formerly known as nebostinel, is a positive allosteric modulator of the glycine site of the NMDA receptor which is under investigation for Rottapharm for the treatment of schizophrenia and cocaine dependence.[1][2][3][4][5][6] It shows cognition- and memory-enhancing effects in animal models.[7][8][9] As of June 2015, it is in phase II clinical trials for both schizophrenia and cocaine abuse.[10]

See also

References

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External links


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