Neurophysin II
| arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal) | |
|---|---|
| Identifiers | |
| Symbol | AVP |
| Alt. symbols | ARVP |
| Entrez | 551 |
| HUGO | 894 |
| OMIM | 192340 |
| RefSeq | NM_000490 |
| UniProt | P01185 |
| Other data | |
| Locus | Chr. 20 p13 |
Neurophysin II is a carrier protein which binds vasopressin. It is generated from the same precursor as vasopressin.
It can be associated with neurohypophyseal diabetes insipidus.[1]
Neurophysin II is also known as a stimulator of Prolactin secretion.
Structure
The amino acid sequence of Neurophysin II is:
NH2 - Ala - Met - Ser - Asp - Leu - Glu - Leu - Arg - Gln - Cys - Leu - Pro - Cys - Gly - Pro - Gly - Gly - Lys - Gly - Arg - Cys - Phe - Gly - Pro - Ser - Ile - Cys - Cys - Ala - Asp - Glu - Leu - Gly - Cys - Phe - Val - Gly - Thr - Ala - Glu - Ala - Leu - Arg - Cys - Gln - Glu - Glu - Asn - Tyr - Leu - Pro - Ser - Pro - Cys - Gln - Ser - Gly - Gln - Lys - Ala - Cys - Gly - Ser - Gly - Gly - Arg - Cys - Ala - Ala - Phe - Gly - Val - Cys - Cys - Asn - Asp - Glu - Ser - Cys - Val - Thr - Glu - Pro - Glu - Cys - Arg - Glu - Gly - Phe - His - Arg - Arg - Ala - OH
(Disulfide - bridge: - 10-54; - 13-27; - 21-44; - 28-34; - 61-73; - 67-85; - 74-79)
Clinical significance
Point mutations in neurophysin II underline most cases of hereditary hypothalamic diabetes insipidus, a disorder resulting from insufficient ADH release into systemic circulation.
References
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<references />, or <references group="..." />External links
- Neurophysin II at the US National Library of Medicine Medical Subject Headings (MeSH)
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