PER3

Period circadian clock 3
Identifiers
Symbols	PER3 ; GIG13
External IDs	OMIM: 603427 MGI: 1277134 HomoloGene: 7886 GeneCards: PER3 Gene
Gene ontology Molecular function • protein binding • kinase binding • ubiquitin protein ligase binding Cellular component • nucleus • cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • circadian regulation of gene expression • regulation of circadian sleep/wake cycle, sleep Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE PER3 221045 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8863	18628
Ensembl	ENSG00000049246	ENSMUSG00000028957
UniProt	P56645	O70361
RefSeq (mRNA)	NM_001289861	NM_001289877
RefSeq (protein)	NP_001276790	NP_001276806
Location (UCSC)	Chr 1: 7.78 – 7.85 Mb	Chr 4: 151 – 151.04 Mb
PubMed search	[1]	[2]

The PER3 gene encodes the period circadian protein homolog 3 protein in humans.

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.

See also

• PER1
• PER2

External links

• PER3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.