PTPRB
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Receptor-type tyrosine-protein phosphatase beta or VE-PTP is an enzyme specifically expressed in endothelial cells that in humans is encoded by the PTPRB gene.[1][2]
Function
VEPTP is a member of the classical protein tyrosine phosphatase (PTP) family. The deletion of the gene in mouse models was shown to be emryonically lethal,[3] thus indicating that it is important for vasculogenesis and blood vessel development. In addition it was shown to participate in adherens junctions and regulate vascular permeability.[4]
Interactions
VE-PTP contains an extracellular domain composed of multiple fibronectin type_III repeats, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to R3 receptor subtype PTPs. The extracellular region was shown to interact with the angiopoietin receptor Tie-2.[2] and with the adhesion protein VE-cadherin.[5]
VE-PTP was also found to interact with Grb2 and plakoglobin through its cytoplasmatic domain.
References
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