Palmitoyl(protein) hydrolase
| palmitoyl-(protein) hydrolase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.1.2.22 | ||||||||
| CAS number | Template:CAS | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a palmitoyl[protein] hydrolase (EC 3.1.2.22) is an enzyme that catalyzes the chemical reaction
- palmitoyl[protein] + H2O
palmitate + protein
Thus, the two substrates of this enzyme are [[palmitoyl[protein]]] and H2O, whereas its two products are palmitate and protein.
This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is palmitoyl[protein] hydrolase. Other names in common use include palmitoyl-protein thioesterase, and palmitoyl-(protein) hydrolase. This enzyme participates in fatty acid elongation in mitochondria.
Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1EH5, 1EI9, 1EXW, and 1PJA.
References
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