Protein C inhibitor

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
	PDB rendering based on 1lq8.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1LQ8, 1PAI, 2HI9, 2OL2, 2PAI, 3DY0
Identifiers
Symbols	SERPINA5 ; PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI
External IDs	OMIM: 601841 MGI: 107817 HomoloGene: 20159 GeneCards: SERPINA5 Gene
Gene ontology
Molecular function	• retinoic acid binding; • protease binding; • serine-type endopeptidase inhibitor activity; • protein binding; • glycosaminoglycan binding; • heparin binding; • phosphatidylcholine binding; • acrosin binding;
Cellular component	• acrosomal membrane; • extracellular region; • extracellular space; • external side of plasma membrane; • membrane; • platelet alpha granule; • platelet dense tubular network; • protein C inhibitor-TMPRSS7 complex; • protein C inhibitor-TMPRSS11E complex; • protein C inhibitor-PLAT complex; • protein C inhibitor-PLAU complex; • protein C inhibitor-thrombin complex; • protein C inhibitor-KLK3 complex; • protein C inhibitor-plasma kallikrein complex; • protein complex; • extracellular exosome; • protein C inhibitor-coagulation factor V complex; • protein C inhibitor-coagulation factor Xa complex; • protein C inhibitor-coagulation factor XI complex;
Biological process	• lipid transport; • spermatogenesis; • fusion of sperm to egg plasma membrane; • blood coagulation; • negative regulation of endopeptidase activity; • negative regulation of hydrolase activity;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
Species	Human
Entrez	5104
Ensembl	ENSG00000188488
UniProt	P05154
RefSeq (mRNA)	NM_000624
RefSeq (protein)	NP_000615
Location (UCSC)	Chr 14:; 94.56 – 94.59 Mb
PubMed search	[1]
	v; t; e;

Protein C inhibitor (PCI, SERPINA5) is a serine protease inhibitor (serpin) which limits the activity of protein C (an anticoagulant).

An N-terminal fragment of PCI is a possible serum biomarker for prostate cancer.^[1]

Protein C inhibitor is activated by heparin against thrombin.^[2]

Interactions

Protein C inhibitor has been shown to interact with prostate specific antigen,^[3]^[4] protein C^[5]^[6] and PLAU.^[5]^[7]

References

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External links

The MEROPS online database for peptidases and their inhibitors: I04.004
Protein C inhibitor at the US National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

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v t e Serpins
inhibitory	Alpha 1-antichymotrypsin Alpha 1-antitrypsin Alpha 2-antiplasmin Antithrombin C1-inhibitor Heparin cofactor II Protein C inhibitor Plasminogen activator inhibitor-1 Plasminogen activator inhibitor-2 Protein Z-related protease inhibitor SERPINA1 SERPINA2 SERPINA3 SERPINA4 SERPINA5 SERPINA6 SERPINA7 SERPINA8 SERPINA9 SERPINA14 SERPINB1 SERPINB2 SERPINB3 SERPINB4 SERPINB5 SERPINB6 SERPINB7 SERPINB8 SERPINB9 SERPINB13 SERPINC1 SERPIND1 SERPINE1 SERPINE2 SERPINE2 SERPINF1 SERPING1 SERPINH1 SERPINI1 SERPINI2
Cross class inhibitory	MENT SCCA-1 crmA
noninhibitory	Heat shock protein 47 Maspin Ovalbumin SERPINF1 Thyroxine-binding globulin Transcortin SERPINF1
see also disorders of globin and globulin proteins

Protein C inhibitor

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