RNF8
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). E3 ubiquitin-protein ligase RNF8 is an enzyme that in humans is encoded by the RNF8 gene.[1][2][3]
Function
The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as a ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]
Interactions
RNF8 has been shown to interact with Retinoid X receptor alpha.[4]
See also
References
Further reading
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External links
- RNF8 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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