Rostral ventrolateral medulla
The rostral ventrolateral medulla (RVLM), also known as the pressor area of the medulla, is a brain region that is responsible for basal and reflex control of sympathetic activity associated with cardiovascular function.[1] Abnormally elevated sympathetic activity in the RVLM is associated with various cardiovascular diseases, such as heart failure and hypertension.[1] The RVLM is notably involved in the baroreflex.
It receives inhibitory GABAergic input from the caudal ventrolateral medulla (CVLM). The RVLM is a primary regulator of the sympathetic nervous system; it sends catecholaminergic projections to the sympathetic preganglionic neurons in the spinal cord via reticulospinal tract.
Physostigmine, a choline-esterase inhibitor, elevates endogenous levels of acetylcholine by stimulation of the RVLM.[2] Orexinergic neurons from the lateral hypothalamus output in the RVLM.
See also
References
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- ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Medullary pressor area: site of action of intravenous physostigmine
