TREX1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Three prime repair exonuclease 1 is an enzyme that in humans is encoded by the TREX1 gene.[1][2][3][4]
Function
This gene encodes the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, RVCL (Retinal Vasculopathy with Cerebral Leukodystrophy), and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene.[4]
clinical relevance
TREX1 helps HIV‑1 to evade cytosolic sensing by degrading viral cDNA in the cytoplasm[5]
References
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<references />, or <references group="..." />Further reading
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External links
- GeneReviews/NCBI/NIH/UW entry on Aicardi-Goutières Syndrome
- OMIM entries on Aicardi-Goutieres syndrome
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This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it. |
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