TRIM24
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1α (TIF1α) is a protein that, in humans, is encoded by the TRIM24 gene.[1][2][3]
Function
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[1]
Interactions
TRIM24 has been shown to interact with Mineralocorticoid receptor,[2][4] TRIM33,[5] Estrogen receptor alpha[2][6] and Retinoid X receptor alpha.[2][7]
See also
References
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External links
- TRIM24 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- NURSA C150
Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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