Template:PBB/4233

MET proto-oncogene, receptor tyrosine kinase
250px Crystallographic structure of MET. PDB rendering based on 1r0p.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1FYR, 1R0P, 1R1W, 1SHY, 1SSL, 1UX3, 2G15, 2RFN, 2RFS, 2UZX, 2UZY, 2WD1, 2WGJ, 2WKM, 3A4P, 3BUX, 3C1X, 3CCN, 3CD8, 3CE3, 3CTH, 3CTJ, 3DKC, 3DKF, 3DKG, 3EFJ, 3EFK, 3F66, 3F82, 3I5N, 3L8V, 3LQ8, 3Q6U, 3Q6W, 3QTI, 3R7O, 3RHK, 3U6H, 3U6I, 3VW8, 3ZBX, 3ZC5, 3ZCL, 3ZXZ, 3ZZE, 4AOI, 4AP7, 4DEG, 4DEH, 4DEI, 4EEV, 4GG5, 4GG7, 4IWD, 4K3J, 4KNB, 4MXC, 4O3T, 4O3U, 4R1V, 4R1Y, 4XMO, 4XYF
Identifiers
Symbols	MET ; AUTS9; DFNB97; HGFR; RCCP2; c-Met
External IDs	OMIM: 164860 MGI: 96969 HomoloGene: 206 ChEMBL: 3717 GeneCards: MET Gene
EC number	2.7.10.1
Gene ontology Molecular function • protein tyrosine kinase activity • hepatocyte growth factor-activated receptor activity • protein binding • ATP binding • protein phosphatase binding Cellular component • extracellular region • plasma membrane • integral component of plasma membrane • basal plasma membrane • cell surface • integral component of membrane Biological process • activation of MAPK activity • endothelial cell morphogenesis • liver development • placenta development • signal transduction • cell surface receptor signaling pathway • axon guidance • brain development • skeletal muscle tissue development • cell proliferation • positive regulation of glucose transport • muscle cell migration • myotube differentiation • peptidyl-tyrosine phosphorylation • adult behavior • glucose homeostasis • positive regulation of transcription from RNA polymerase II promoter • protein autophosphorylation • hepatocyte growth factor receptor signaling pathway • branching morphogenesis of an epithelial tube • positive chemotaxis • myoblast proliferation • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling • semaphorin-plexin signaling pathway • negative regulation of hydrogen peroxide-mediated programmed cell death • positive regulation of endothelial cell chemotaxis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4233	17295
Ensembl	ENSG00000105976	ENSMUSG00000009376
UniProt	P08581	n/a
RefSeq (mRNA)	NM_000245	NM_008591
RefSeq (protein)	NP_000236	NP_032617
Location (UCSC)	Chr 7: 116.67 – 116.8 Mb	Chr 6: 17.46 – 17.57 Mb
PubMed search	[1]	[2]