Template:PBB/6925

Transcription factor 4
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2KWF
Identifiers
Symbols	TCF4 ; E2-2; ITF-2; ITF2; PTHS; SEF-2; SEF2; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; TCF-4; bHLHb19
External IDs	OMIM: 602272 MGI: 98506 HomoloGene: 2407 GeneCards: TCF4 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor activity, TFIIB-class binding • TFIIB-class transcription factor binding • DNA binding • transcription factor activity, sequence-specific DNA binding • protein binding • protein C-terminus binding • protein homodimerization activity • bHLH transcription factor binding • protein heterodimerization activity • E-box binding Cellular component • nucleus • transcription factor complex Biological process • DNA-templated transcription, initiation • transcription initiation from RNA polymerase II promoter • positive regulation of neuron differentiation • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • protein-DNA complex assembly Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6925	21413
Ensembl	ENSG00000196628	ENSMUSG00000053477
UniProt	P15884	Q60722
RefSeq (mRNA)	NM_001083962	NM_001083967
RefSeq (protein)	NP_001077431	NP_001077436
Location (UCSC)	Chr 18: 55.22 – 55.66 Mb	Chr 18: 69.34 – 69.69 Mb
PubMed search	[1]	[2]