Uramustine

Uramustine

Systematic (IUPAC) name
5-[bis(2-chloroethyl)amino]-1H-pyrimidine-2,4-dione
Pharmacokinetic data
Protein binding	5%
Excretion	Renal
Identifiers
CAS Number	66-75-1 Y
ATC code	none
PubChem	CID: 6194
IUPHAR/BPS	7621
DrugBank	DB00791 N
ChemSpider	5959 N
UNII	W7KQ46GJ8U N
KEGG	D06265 Y
ChEMBL	CHEMBL1488 N
Chemical data
Formula	C8H11Cl2N3O2
Molecular mass	252.097 g/mol
SMILES O=C1C(\N(CCCl)CCCl)=C/NC(=O)N1
InChI InChI=1S/C8H11Cl2N3O2/c9-1-3-13(4-2-10)6-5-11-8(15)12-7(6)14/h5H,1-4H2,(H2,11,12,14,15) N Key:IDPUKCWIGUEADI-UHFFFAOYSA-N N
NY (what is this?)  (verify)

Uramustine (INN) or uracil mustard is a chemotherapy drug which belongs to the class of alkylating agents. It is used in lymphatic malignancies such as non-Hodgkin's lymphoma. It works by damaging DNA, primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division. The DNA damage leads to apoptosis of the affected cells. Bone marrow suppression and nausea are the main side effects.

Chemically it is a derivative of nitrogen mustard and uracil.