ABT-239

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ABT-239
ABT-239.svg
Systematic (IUPAC) name
4-(2-{2-[(2R)-2-Methylpyrrolidin-1-yl]ethyl}-
benzofuran-5-yl)benzonitrile
Identifiers
CAS Number 460746-46-7
460746-51-4 (racemic)
460749-29-5 (S-isomer)
PubChem CID: 9818903
IUPHAR/BPS 1218
ChemSpider 7994652 YesY
ChEMBL CHEMBL351231 YesY
Chemical data
Formula C22H22N2O
Molecular mass 330.42 g/mol
  • N#CC1=CC=C(C2=CC3=C(C=C2)OC(CCN4[C@@H](CCC4)C)=C3)C=C1
  • InChI=1S/C22H22N2O/c1-16-3-2-11-24(16)12-10-21-14-20-13-19(8-9-22(20)25-21)18-6-4-17(15-23)5-7-18/h4-9,13-14,16H,2-3,10-12H2,1H3/t16-/m1/s1 YesY
  • Key:KFHYZKCRXNRKRC-MRXNPFEDSA-N YesY
  (verify)

ABT-239 is an H3-receptor inverse agonist developed by Abbott. It has stimulant and nootropic effects, and has been investigated as a treatment for ADHD, Alzheimer's disease, and schizophrenia.[1][2][3][4] ABT-239 is more active at the human H3 receptor than comparable agents such as thioperamide, ciproxifan, and cipralisant. It was ultimately dropped from human trials after showing the dangerous cardiac side effect of QT prolongation,[5] but is still widely used in animal research into H3 antagonists / inverse agonists.

References

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External links



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