JNJ-5207852

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JNJ-5207852
JNJ-5207852.svg
Names
Preferred IUPAC name
1-{3-[4-(Piperidin-1-ylmethyl)phenoxy]propyl}piperidine
Systematic IUPAC name
1-({4-[3-(Piperidin-1-yl)propoxy]phenyl}methyl)piperidine
Identifiers
Abbreviations JNJ-5207852
ChEBI CHEBI:312531 N
ChEMBL ChEMBL129542 YesY
ChemSpider 2046959 YesY
1256
Jmol 3D model Interactive image
Interactive image
MeSH JNJ-5207852
PubChem 2766326
  • InChI=1S/C20H32N2O/c1-3-12-21(13-4-1)16-7-17-23-20-10-8-19(9-11-20)18-22-14-5-2-6-15-22/h8-11H,1-7,12-18H2 YesY
    Key: PTKHFRNHJULJKT-UHFFFAOYSA-N YesY
  • O(c1ccc(cc1)CN2CCCCC2)CCCN3CCCCC3
  • O(c1ccc(cc1)CN2CCCCC2)CCCN3CCCCC3
Properties
C20H32N2O
Molar mass 316.480 g/mol
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

JNJ-5207852 is a histamine antagonist selective for the H3 subtype. It has stimulant and nootropic effects in animal studies,[1] and has been suggested as a possible treatment for memory defects associated with epilepsy.[2] JNJ-5207852 itself did not progress to clinical development due to poor pharmacokinetic characteristics, but the related compound JNJ-17216498 is currently in Phase II clinical trials for the treatment of narcolepsy.[3]

References

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  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Jia F, Kato M, Dai H, Xu A, Okuda T, Sakurai E, Okamura N, Lovenberg TW, Barbier A, Carruthers NI, Iinuma K, Yanai K. Effects of histamine H(3) antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice. Neuropharmacology. 2006 Mar;50(4):404-11. PMID 16310812
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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