Cabotegravir
From Infogalactic: the planetary knowledge core
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1051375-10-0 ![]() |
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ChemSpider | 30829503 |
Jmol 3D model | Interactive image |
PubChem | 54713659 |
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Properties | |
C19H17F2N3O5 | |
Molar mass | 405.36 g·mol−1 |
Vapor pressure | {{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references | |
Cabotegravir (USAN[1] and INN[2]) (also known as S/GSK1265744 or GSK744) is an investigational new drug under development for the treatment of HIV infection. It is an integrase inhibitor, with a carbamoyl pyridone structure similar to dolutegravir.[3] In investigational studies, the agent has been packaged into nanoparticles (GSK744LAP) conferring an exceptionally long half-life of 21–50 days following a single dose. In theory, this would make possible suppression of HIV with dosing as infrequently as once every three months.[4]
References
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- ↑ PrEP GSK744 Integrase Administered Monthly Perhaps Quarterly Prevents HIV-Infection in Monkeys. 20th Conference on Retroviruses and Opportunistic Infections. Atlanta, GA March 3–6, 2013.
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- Integrase inhibitors
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- 4-Pyridones
- Antiinfective agent stubs