Filaminast
From Infogalactic: the planetary knowledge core
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| Systematic (IUPAC) name | |
|---|---|
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[1-(3-cyclopentyloxy-4-methoxyphenyl)ethylideneamino] carbamate
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| Identifiers | |
| CAS Number | 141184-34-1 |
| ATC code | none |
| PubChem | CID: 9578243 |
| DrugBank | DB02660 |
| ChemSpider | 7852607 |
| UNII | CDD69JC61J  |
| KEGG | D04185 |
| Chemical data | |
| Formula | C15H20N2O4 |
| Molecular mass | 292.33 g/mol |
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Filaminast (WAY-PDA 641[1]) was a drug candidate developed by Wyeth-Ayerst.[2]:Table 2 It was a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and an analog of rolipram, which served as a prototype molecule for several development efforts.[3][4]:668, 678 It was discontinued after a Phase II trial showed that its therapeutic window was too narrow; it could not be dosed high enough without causing significant side effects (nausea and vomiting), which was a problem with the rolipram class of molecules.[4]:678
See also
References
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<references />, or <references group="..." />- ↑ Filaminist entry at Pubchem
- ↑ Halpin DM. ABCD of the phosphodiesterase family: interaction and differential activity in COPD. Int J Chron Obstruct Pulmon Dis. 2008;3(4):543-61. PMID 19281073 PMC 2650605
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 4.0 4.1 McKenna, JM and Muller, GW. Medicinal Chemistry of PDE4 Inhibitors. Chapter 33 in Cyclic Nucleotide Phosphodiesterases in Health and Disease, Eds Joseph A. Beavo et al. CRC Press, Dec 5, 2006 ISBN 9781420020847
Categories:
- Pages with reference errors
- Chemical articles having calculated molecular weight overwritten
- Infobox drug articles without a structure image
- Articles without EBI source
- Articles without InChI source
- Drugs not assigned an ATC code
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Phenol ethers
- Carbamates
- PDE4 inhibitors
