Propentofylline

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Propentofylline
Propentofylline.svg
Systematic (IUPAC) name
3-methyl-1-(5-oxohexyl)-7-propyl-3,7-dihydro-1H-purine-2,6-dione
Clinical data
AHFS/Drugs.com International Drug Names
Identifiers
CAS Number 55242-55-2 YesY
ATC code N06BC02 (WHO) QC04AD90 (WHO)
PubChem CID: 4938
ChemSpider 4769
UNII 5RTA398U4H YesY
Chemical data
Formula C15H22N4O3
Molecular mass 306.360 g/mol
  • CCCn1cnc2c1c(=O)n(c(=O)n2C)CCCCC(=O)C
  • InChI=1S/C15H22N4O3/c1-4-8-18-10-16-13-12(18)14(21)19(15(22)17(13)3)9-6-5-7-11(2)20/h10H,4-9H2,1-3H3
  • Key:RBQOQRRFDPXAGN-UHFFFAOYSA-N
  (verify)

Propentofylline (HWA 285) is a xanthine derivative with purported neuroprotective effects.

Pharmacology

It is a phosphodiesterase inhibitor.[1]

It also acts as an adenosine reuptake inhibitor.[1][2][3]

Uses

It was studied as a possible treatment for Alzheimer's disease and multi-infarct dementia.[4][5]

Propentofylline has also been studied, to a lesser extent, as a possible adjunct in the treatment of ischemic stroke, due to its vasodilating properties.[6][7]

Propentofylline is in use in veterinary medicine as a geriatric preparation for old dogs.

See also

References

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