GNAI3

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
250px PDB rendering based on 1agr.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2IHB, 2ODE, 2V4Z, 4G5O, 4G5R, 4G5S
Identifiers
Symbols	GNAI3 ; 87U6; ARCND1
External IDs	OMIM: 139370 MGI: 95773 HomoloGene: 55975 ChEMBL: 4221 GeneCards: GNAI3 Gene
Gene ontology Molecular function • GTPase activity • signal transducer activity • protein binding • GTP binding • protein domain specific binding • G-protein beta/gamma-subunit complex binding • G-protein coupled serotonin receptor binding • GTPase activating protein binding • metal ion binding Cellular component • cytoplasm • lysosomal membrane • Golgi apparatus • centrosome • heterotrimeric G-protein complex • plasma membrane • membrane • midbody • zymogen granule • membrane raft • extracellular exosome Biological process • transport • vesicle fusion • cell cycle • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • negative regulation of adenylate cyclase activity • synaptic transmission • blood coagulation • metabolic process • platelet activation • cell division Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE GNAI3 201180 s at tn.png
File:PBB GE GNAI3 201179 s at tn.png
File:PBB GE GNAI3 201181 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2773	14679
Ensembl	ENSG00000065135	ENSMUSG00000000001
UniProt	P08754	Q9DC51
RefSeq (mRNA)	NM_006496	NM_010306
RefSeq (protein)	NP_006487	NP_034436
Location (UCSC)	Chr 1: 109.55 – 109.62 Mb	Chr 3: 108.11 – 108.15 Mb
PubMed search	[1]	[2]

Guanine nucleotide-binding protein G(k) subunit alpha is a protein that in humans is encoded by the GNAI3 gene.

Interactions

GNAI3 has been shown to interact with:

• RGS10
• RGS12,
• RGS14,
• RGS16,
• RGS18,
• RGS19,
• RGS5,
• RIC8A, and
• S1PR1.

See also

• Gi alpha subunit