MS4A3

Membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
Identifiers
Symbols	MS4A3 ; CD20L; HTM4
External IDs	OMIM: 606498 MGI: 2158468 HomoloGene: 4472 GeneCards: MS4A3 Gene
Gene ontology Molecular function • protein binding Cellular component • endomembrane system • integral component of membrane • perinuclear region of cytoplasm Biological process • regulation of cell cycle Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE MS4A3 210254 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	932	170813
Ensembl	ENSG00000149516	ENSMUSG00000024681
UniProt	Q96HJ5	Q920C4
RefSeq (mRNA)	NM_001031666	NM_133246
RefSeq (protein)	NP_001026836	NP_573509
Location (UCSC)	Chr 11: 60.06 – 60.07 Mb	Chr 19: 11.63 – 11.64 Mb
PubMed search	[1]	[2]

Membrane-spanning 4-domains subfamily A member 3 is a protein that in humans is encoded by the MS4A3 gene.

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described.

Interactions

MS4A3 has been shown to interact with CDKN3.