Myelin-associated glycoprotein

Myelin associated glycoprotein
Identifiers
Symbols	MAG ; GMA; S-MAG; SIGLEC-4A; SIGLEC4A
External IDs	OMIM: 159460 HomoloGene: 1771 ChEMBL: 5807 GeneCards: MAG Gene
Gene ontology Molecular function • receptor binding • protein kinase binding • carbohydrate binding Cellular component • cytoplasm • plasma membrane • integral component of membrane • paranode region of axon • myelin sheath adaxonal region • Schmidt-Lanterman incisure • mesaxon Biological process • cell adhesion • blood coagulation • substantia nigra development • positive regulation of myelination • neurotrophin TRK receptor signaling pathway • positive regulation of astrocyte differentiation • regulation of axonogenesis • negative regulation of axonogenesis • leukocyte migration • cellular response to mechanical stimulus Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4099	17136
Ensembl	ENSG00000105695	ENSMUSG00000036634
UniProt	P20916	P20917
RefSeq (mRNA)	NM_001199216	NM_010758
RefSeq (protein)	NP_001186145	NP_034888
Location (UCSC)	Chr 19: 35.29 – 35.31 Mb	Chr 7: 30.9 – 30.91 Mb
PubMed search	[1]	[2]

myelin associated glycoprotein
Identifiers
Symbol	MAG
Alt. symbols	GMA
Entrez	4099
HUGO	6783
OMIM	159460
RefSeq	NM_080600
UniProt	P20916
Other data
Locus	Chr. 19 q13.1

Myelin-associated glycoprotein (MAG, Siglec-4) is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR. MAG is believed to be involved in myelination during nerve regeneration.

See also

• Myelin

External links

• Myelin-associated glycoprotein at the US National Library of Medicine Medical Subject Headings (MeSH)