SB-334867

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SB-334867
File:SB-334,867.svg
Systematic (IUPAC) name
1-(2-methylbenzoxazol-6-yl)-3-[1,5]naphthyridin-4-yl urea
Identifiers
CAS Number 249889-64-3 N
PubChem CID: 6604926
IUPHAR/BPS 1703
ChemSpider 5037182 YesY
ChEMBL CHEMBL291536 YesY
Chemical data
Formula C17H13N5O2
Molecular mass 319.317 g/mol
  • O=C(Nc1c2ncccc2ncc1)Nc3ccc4nc(oc4c3)C
  • InChI=1S/C17H13N5O2/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14/h2-9H,1H3,(H2,18,21,22,23) YesY
  • Key:AKMNUCBQGHFICM-UHFFFAOYSA-N YesY
 NYesY (what is this?)  (verify)

SB-334867 is an orexin antagonist. It was the first non-peptide antagonist developed that is selective for the orexin receptor subtype OX1, with around 50x selectivity for OX1 over OX2 receptors.[1] It has been shown to produce sedative and anorectic effects in animals,[2] and has been useful in characterising the orexinergic regulation of brain systems involved with appetite and sleep,[3][4][5][6][7][8] as well as other physiological processes.[9][10][11][12] Orexin antagonists have multiple potential clinical applications including the treatment of drug addiction, insomnia, obesity and diabetes.[13][14][15][16][17][18][19][20]

References

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  1. REDIRECT Template:Peptide receptor modulators

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Stub icon

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