Vedolizumab

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Vedolizumab
Monoclonal antibody
Type Whole antibody
Source Humanized
Target Integrin α4β7
Clinical data
Trade names Entyvio
AHFS/Drugs.com Multum Consumer Information
Pregnancy
category
  • US: B (No risk in non-human studies)
Legal status
Identifiers
CAS Number 943609-66-3 N
ATC code L04AA33 (WHO)
UNII 9RV78Q2002 YesY
Chemical data
Formula C6528H10072N1732O2042S42
Molecular mass 146.8 kg/mol
 NYesY (what is this?)  (verify)

Vedolizumab (trade name Entyvio) is a monoclonal antibody developed by Millennium Pharmaceuticals, Inc (a subsidiary of Takeda Pharmaceuticals) for the treatment of ulcerative colitis and Crohn's disease.[1] It binds to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1).[1][2] Blocking the α4β7 integrin results in gut-selective anti-inflammatory activity.[3] It is marketed under the trade name Entyvio.

Medical uses

Ulcerative colitis

Vedolizumab has been investigated in one main study in adult patients. Patients with moderate to severe active disease in whom conventional therapy or TNF-alpha antagonists were ineffective or could not be tolerated received either vedolizumab or placebo. The main measure of effectiveness was the proportion of patients whose symptoms improved after 6 weeks of treatment. Vedolizumab was shown to be more effective than placebo: 47% (106 out of 225) of patients who received vedolizumab showed an improvement in symptoms, compared with 26% (38 out of 149) of patients who received placebo. The study also showed that vedolizumab maintained the effect up to 52 weeks more effectively than placebo.[4]

Crohn's disease

In one main study in adult patients with moderate to severe active Crohn’s disease in whom conventional therapy or TNF-alpha antagonists were ineffective or could not be tolerated vedolizumab was shown to be more effective than placebo: 15% (32 out of 220) of patients receiving vedolizumab showed improved symptoms after 6 weeks of treatment, compared with 7% (10 out of 148) of patients on placebo. The maintenance of the effect up to 52 weeks was more effective with vedolizumab than with placebo.[4]

History

The cell line used to develop vedolizumab was created by physician scientists at the Massachusetts General Hospital in Boston, Massachusetts, as a result of work executed at Dr. Robert B. Colvin's lab, from the Department of Pathology. An antibody was isolated that reacted with long term activated antigen-specific (tetanus toxoid) T lymphocytes originally isolated from blood lymphocytes. The cell lines were created in Dr. Jim T. Kurnick's lab. Although the antibody did not block primary activation of T lymphocytes, it appeared late after activation with a number of lymphocytic stimuli,and was named "Act-1" because it was the first activation marker identified by this group of investigators. Dr. Andrew Lazarovits, a postdoctoral fellow in the laboratory, discovered the murine homologue of MLN0002,[5][6] chiefly published the original key papers, and up until the late 90's, coordinated, and led the studies for its development and application for Crohn's Disease and Ulcerative Colitis. Dr. Lynn Baird's group showed the antibody reacted with a single protein band of 63Kd, and Dr. Atul Bhan's group showed that it stained tissue lymphocytes but did not react with non-lymphoid tissues. Although Act-1 had limited efficacy in its ability to prevent kidney rejection in a sub-human primate transplantation model, Dr. Lazarovits continued to investigate the activities of Act-1 when he returned to Canada to become the Director of Transplantation at the University of Western Ontario.[6]

It was later determined that the Act-1 monoclonal antibody reacted with an alpha-4/beta-7 integrin that was subsequently shown to interact with a gut-associated addressin, MadCAM. Early work with Yacyshyn showed differential expression in inflammatory bowel disease (5). Dr. Lazarovits isolated the antibody to produce the murine homologue MLN002 which he licensed with the Massachusetts General Hospital to Millennium Pharmaceuticals of Boston for further development.[5] Scientists at LeukoSite realized the potential of this antibody to treat inflammatory bowel disease, and this company was eventually acquired by Millennium which took an exclusive license to the cell line from Massachusetts General Hospital. In vivo proof of concept ultimately led to the decision to humanize the antibody and move it into clinical trials as "Vedolizumab." In addition to its reactivity to gut-associated lymphoid tissues, Act-1 antibody also stains large numbers of lymphocytes in rheumatoid synovium, and has been shown by Dr. A. A. Ansari of Emory University to prevent or delay onset of AIDS in a monkey-model of Simian Immunodeficiency Virus-induced AIDS. Thus, reactivity with this antibody may show widespread applicability in inflammatory processes of diverse etiologies.

Approval status

Takeda has filed a Marketing Authorization Application (MAA) in the European Union on March 7, 2013[7] and a Biologic License Application (BLA) with the U.S. Food and Drug Administration on June 21, 2013 for both Crohn's Disease and Ulcerative Colitis.[8] On September 4, 2013, Vedolizumab was given a Priority Review Status, which functions to expedite potential acceptance to market.[9]

On December 9, 2013, the Gastrointestinal Drugs Advisory Committee (GIDAC) & Drug Safety and Risk Management Advisory Committee (DSaRM) discussed the Vedolizumab application for approval for both UC and CD under the trade name Entyvio.[10] The voting went as follows: 1. Safety and efficacy data outweigh potential risks 21-0 2. In favour of UC treatment 21-0 3. In favour for CD treatment 20-1.[11][12] Although GIDAC/DSaRM were a non-binding advisory committee, their opinions as field experts represent one of the last steps towards drug acceptance.

On 20 March 2014, the Committee for Medicinal Products for Human Use (CHMP, the committee advising the European Commission) adopted a positive opinion, recommending the granting of a marketing authorization for Vedolizumab (brand name Entyvio).[13]

On 20 May 2014, vedolizumab (Entyvio) was approved by the FDA for treatment of both moderate-to-severe ulcerative colitis and moderate-to-severe Crohn's disease.[14] On May 27, 2014, Entyvio was approved for the treatment of both ulcerative colitis and Crohn's disease in the 28 European Union states as well as Norway, Iceland and Lichtenstein. On April 28, 2015 Health Canada approved Entyvio. [15]

Research

Vedolizumab eventually completed a number of phase 3 clinical trials[16][17] for Crohn's Disease and Ulcerative Colitis (GEMINI I,[18] GEMINI II,[19] and GEMINI III[20]) that demonstrate that vedolizumab is an effective and well tolerated drug.[21][22] The results of the GEMINI 1 and GEMINI 2 randomized, placebo controlled multicenter trials of induction and maintenance therapy in Crohn's disease and ulcerative colitis have been published.[23][24] An additional clinical trial, GEMINI LTS (Long-term Safety), is still being run.[25]

References

  1. ↑ 1.0 1.1 Statement On A Nonproprietary Name Adopted By The USAN Council - Vedolizumab, American Medical Association.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ 4.0 4.1 Summary of the risk management plan (RMP) for Entyvio, EMA.
  5. ↑ 5.0 5.1 Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ 6.0 6.1 Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  8. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  9. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  10. ↑ http://www.fdalive.com/results.cfm
  11. ↑ http://www.takeda.com/news/files/20131210_04_en.pdf
  12. ↑ https://research.tdwaterhouse.ca/research/public/Markets/NewsArticle/100-343p7866-1
  13. ↑ http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/002782/smops/Positive/human_smop_000663.jsp&mid=WC0b01ac058001d127
  14. ↑ http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm398065.htm
  15. ↑ http://www.hc-sc.gc.ca/dhp-mps/prodpharma/sbd-smd/drug-med/sbd_smd_2015_entyvio_169414-eng.php
  16. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  17. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  18. ↑ Clinical trial number NCT00783718 at ClinicalTrials.gov
  19. ↑ Clinical trial number NCT00783692 at ClinicalTrials.gov
  20. ↑ Clinical trial number NCT01224171 at ClinicalTrials.gov
  21. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  22. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  23. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  24. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  25. ↑ Clinical trial number NCT00790933 at ClinicalTrials.gov

(5) Yacyshyn BR, Lazarovits A, Tsai V, Matejko K, Crohns disease, ulcerative colitis and normal intestinal lymphocytes express integrins in a dissimilar pattern. Gastroenterology 1994 (107), 1364-1371.

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