Bexlosteride

Bexlosteride
	File:Bexlosteride pic.png
Systematic (IUPAC) name
	(4aS,10bR)-8-chloro-4-methyl-1,2,4a,5,6,10b-hexahydrobenzo[f]quinolin-
Clinical data
Legal status	Uncontrolled;
Routes of; administration	Oral
Identifiers
CAS Number	202189-78-4
ATC code	none
PubChem	CID: 166562
ChemSpider	145762
UNII	36X732P4P0
ChEMBL	CHEMBL24955
Chemical data
Formula	C14H16ClNO
Molecular mass	249.73594 g/mol
	SMILES CN1C2CCC3=C(C2CCC1=O)C=CC(=C3)Cl ;
	InChI InChI=1S/C14H16ClNO/c1-16-13-6-2-9-8-10(15)3-4-11(9)12(13)5-7-14(16)17/h3-4,8,12-13H,2,5-7H2,1H3/t12-,13-/m1/s1 ; Key:WQBIOEFDDDEARX-CHWSQXEVSA-N ;
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Bexlosteride (LY-191,704) is a potent and noncompetitive inhibitor of the enzyme 5α-reductase related to finasteride and dutasteride.^[1]^[2] It is selective for the type I isoform of the enzyme.^[1] It was never marketed.

Synthesis

Preparation of Bexlosteride:^[3]

A QSAR model was developed (1993):^[4]