CCL3

For the aerodrome using the TC LID, CCL3, see Christina Lake Aerodrome.

Chemokine (C-C motif) ligand 3
PDB rendering based on 1b50.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1B50, 1B53, 2X69, 2X6G, 3FPU, 3H44, 3KBX, 4RA8
Identifiers
Symbols	CCL3 ; G0S19-1; LD78ALPHA; MIP-1-alpha; MIP1A; SCYA3
External IDs	OMIM: 182283 HomoloGene: 88430 GeneCards: CCL3 Gene
Gene ontology Molecular function • protein kinase activity • calcium-dependent protein kinase C activity • protein binding • chemokine activity • phospholipase activator activity • kinase activity • CCR1 chemokine receptor binding • CCR5 chemokine receptor binding • chemoattractant activity • identical protein binding Cellular component • extracellular region • extracellular space • intracellular • cytoplasm • cytosol Biological process • MAPK cascade • osteoblast differentiation • cell activation • monocyte chemotaxis • calcium ion transport • cellular calcium ion homeostasis • exocytosis • chemotaxis • inflammatory response • cytoskeleton organization • G-protein coupled receptor signaling pathway • cell-cell signaling • behavior • regulation of cell shape • response to toxic substance • positive regulation of gene expression • negative regulation of gene expression • T cell chemotaxis • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • calcium-mediated signaling • signaling • positive regulation of cell migration • negative regulation of bone mineralization • neutrophil chemotaxis • lipopolysaccharide-mediated signaling pathway • positive regulation of tumor necrosis factor production • eosinophil degranulation • protein kinase B signaling • positive regulation of neuron apoptotic process • positive regulation of GTPase activity • astrocyte cell migration • negative regulation by host of viral transcription • negative regulation of osteoclast differentiation • eosinophil chemotaxis • macrophage chemotaxis • lymphocyte chemotaxis • positive regulation of interleukin-1 beta secretion • positive regulation of inflammatory response • positive regulation of calcium-mediated signaling • positive chemotaxis • positive regulation of protein kinase B signaling • positive regulation of calcium ion transport • regulation of sensory perception of pain • chemokine-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade • response to cholesterol • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to tumor necrosis factor • cellular response to organic cyclic compound • granulocyte chemotaxis • positive regulation of calcium ion import • positive regulation of natural killer cell chemotaxis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6348	20302
Ensembl	ENSG00000274221	ENSMUSG00000000982
UniProt	P10147	P10855
RefSeq (mRNA)	NM_002983	NM_011337
RefSeq (protein)	NP_002974	NP_035467
Location (UCSC)	Chr 17: 36.09 – 36.09 Mb	Chr 11: 83.65 – 83.65 Mb
PubMed search	[1]	[2]

Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the CCL3 gene.

Function

CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes through binding to the receptors CCR1, CCR4 and CCR5.

Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta (CCL4).

CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human tumor necrosis factor or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxygenase inhibitor ibuprofen and CCL3 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.

Interactions

CCL3 has been shown to interact with CCL4. Attracts macrophages, monocytes and neutrophils.

See also

• Macrophage inflammatory proteins