CCL7

Chemokine (C-C motif) ligand 7
250px PDB rendering based on 1bo0.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1BO0, 1NCV
Identifiers
Symbols	CCL7 ; FIC; MARC; MCP-3; MCP3; NC28; SCYA6; SCYA7
External IDs	OMIM: 158106 MGI: 99512 HomoloGene: 4568 GeneCards: CCL7 Gene
Gene ontology Molecular function • protein binding • chemokine activity • heparin binding • CCR1 chemokine receptor binding • CCR2 chemokine receptor binding Cellular component • extracellular region • extracellular space • cell Biological process • monocyte chemotaxis • cellular calcium ion homeostasis • chemotaxis • inflammatory response • cytoskeleton organization • signal transduction • G-protein coupled receptor signaling pathway • cell-cell signaling • regulation of cell shape • response to gamma radiation • positive regulation of cell migration • neutrophil chemotaxis • positive regulation of GTPase activity • eosinophil chemotaxis • chemokine-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to tumor necrosis factor • cellular response to ethanol • positive regulation of natural killer cell chemotaxis Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CCL7 208075 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6354	20306
Ensembl	ENSG00000108688	ENSMUSG00000035373
UniProt	P80098	Q03366
RefSeq (mRNA)	NM_006273	NM_013654
RefSeq (protein)	NP_006264	NP_038682
Location (UCSC)	Chr 17: 34.27 – 34.27 Mb	Chr 11: 82.05 – 82.05 Mb
PubMed search	[1]	[2]

Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine that was previously called monocyte-specific chemokine 3 (MCP3). Due to CCL7 possessing two adjacent N-terminal cysteine residues in its mature protein, it is classified among the subfamily of chemokines known as CC chemokines. CCL7 specifically attracts monocytes, and regulates macrophage function. It is produced by certain tumor cell lines and by macrophages. This chemokine is located on chromosome 17 in humans, in a large cluster containing many other CC chemokines and is most closely related to CCL2 (previously called MCP1).

Interactions

CCL7 has been shown to interact with MMP2.