CXCL11

Chemokine (C-X-C motif) ligand 11
250px PDB rendering based on 1rjt.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1RJT
Identifiers
Symbols	CXCL11 ; H174; I-TAC; IP-9; IP9; SCYB11; SCYB9B; b-R1
External IDs	OMIM: 604852 MGI: 1860203 HomoloGene: 3944 GeneCards: CXCL11 Gene
Gene ontology Molecular function • protein binding • chemokine activity • heparin binding • CXCR3 chemokine receptor binding Cellular component • extracellular region • extracellular space Biological process • positive regulation of leukocyte chemotaxis • chemotaxis • inflammatory response • immune response • signal transduction • G-protein coupled receptor signaling pathway • cell-cell signaling • T cell chemotaxis • positive regulation of cAMP metabolic process • response to lipopolysaccharide • regulation of cell proliferation • positive regulation of cAMP-mediated signaling • positive regulation of release of sequestered calcium ion into cytosol • chemokine-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CXCL11 210163 at tn.png
File:PBB GE CXCL11 211122 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6373	56066
Ensembl	ENSG00000169248	n/a
UniProt	O14625	Q9JHH5
RefSeq (mRNA)	NM_001302123	NM_019494.1
RefSeq (protein)	NP_001289052	NP_062367.1
Location (UCSC)	Chr 4: 76.03 – 76.04 Mb	n/a
PubMed search	[1]	[2]

C-X-C motif chemokine 11 is a protein that in humans is encoded by the CXCL11 gene.

C-X-C motif chemokine 11 is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate.

Gene expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α. This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. CXCL11 is chemotactic for activated T cells. Its gene is located on human chromosome 4 along with many other members of the CXC chemokine family.