Darglitazone

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Darglitazone
Darglitazone structure.svg
Systematic (IUPAC) name
5-[(4-[3-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)propanoyl]phenyl)methyl]-1,3-thiazolidine-2,4-dione
Clinical data
Legal status
  • Development terminated
Identifiers
CAS Number 141200-24-0 YesY
PubChem CID: 60870
ChemSpider 54854 N
UNII AVP9C03Z3K YesY
ChEMBL CHEMBL55624 N
Chemical data
Formula C23H20N2O4S
Molecular mass 420.481 g/mol
  • CC1=C(N=C(O1)C2=CC=CC=C2)CCC(=O)C3=CC=C(C=C3)CC4C(=O)NC(=O)S4
  • InChI=1S/C23H20N2O4S/c1-14-18(24-22(29-14)17-5-3-2-4-6-17)11-12-19(26)16-9-7-15(8-10-16)13-20-21(27)25-23(28)30-20/h2-10,20H,11-13H2,1H3,(H,25,27,28) N
  • Key:QQKNSPHAFATFNQ-UHFFFAOYSA-N N
 NYesY (what is this?)  (verify)

Darglitazone (previously known as CP 86325-2) is a member of the thiazolidinedione class of drugs and an agonist of peroxisome proliferator-activated receptor-γ (PPAR-γ), an orphan member of the nuclear receptor superfamily of transcription factors. It has a variety of insulin-sensitizing effects, such as improving glycemic and lipidemic control, and was researched by Pfizer as a treatment of metabolic disorders such as type 2 diabetes mellitus.[1]

Its development was terminated on November 08, 1999.[2]

Synthesis

Synthesis of darglitazone







References

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