Delta catenin
| catenin (cadherin-associated protein), delta 1 | |
|---|---|
| Identifiers | |
| Symbol | CTNND1 |
| Alt. symbols | CTNND |
| Entrez | 1500 |
| HUGO | 2515 |
| OMIM | 601045 |
| RefSeq | NM_001331 |
| UniProt | O60716 |
| Other data | |
| Locus | Chr. 11 q12.1 |
| catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) | |
|---|---|
| Identifiers | |
| Symbol | CTNND2 |
| Entrez | 1501 |
| HUGO | 2516 |
| OMIM | 604275 |
| RefSeq | NM_001332 |
| UniProt | Q9UQB3 |
| Other data | |
| Locus | Chr. 5 p15.2 |
Delta-1-catenin and Delta-2-catenin are members of a subfamily of proteins with ten Armadillo-repeats. Delta-2-catenin is expressed in the brain where it is important for normal cognitive development.[1] Like beta-catenin and gamma-catenin, delta-catenins seem to interact with presenilins.[2] These catenin-presenilin interaction have implications for cadherin function and regulation of cell-to-cell adhesion.[3]
While beta-catenin acts as a transcription reglatory protein in the Wnt/TCF pathway, delta-catenin 1 has been implicated as a regulator of the NF-κB transcription factor.[4]
Palmitoylation of delta-catenin seems to coordinate activity-dependent changes in synaptic adhesion molecules, synapse structure, and receptor localizations that are involved in memory formation.[5]
References
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