MYLK

Myosin light chain kinase
250px PDB rendering based on 2cqv.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2CQV, 2K0F, 2YR3
Identifiers
Symbols	MYLK ; AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210; MSTP083; MYLK1; smMLCK
External IDs	OMIM: 600922 MGI: 894806 HomoloGene: 14202 ChEMBL: 2428 GeneCards: MYLK Gene
EC number	2.7.11.18
Gene ontology Molecular function • actin binding • calmodulin-dependent protein kinase activity • myosin light chain kinase activity • protein binding • calmodulin binding • ATP binding • metal ion binding Cellular component • stress fiber • cytoplasm • cytosol • cell-cell junction • lamellipodium • cleavage furrow • extracellular exosome Biological process • positive regulation of defense response to virus by host • protein phosphorylation • muscle contraction • smooth muscle contraction • actin filament organization • small GTPase mediated signal transduction • tonic smooth muscle contraction • positive regulation of cell migration • bleb assembly • positive regulation of calcium ion transport • aorta smooth muscle tissue morphogenesis • cellular hypotonic response • positive regulation of wound healing • activation of mitophagy in response to mitochondrial depolarization Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE MYLK 202555 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4638	107589
Ensembl	ENSG00000065534	ENSMUSG00000022836
UniProt	Q15746	B1B1A8
RefSeq (mRNA)	NM_005965	NM_139300
RefSeq (protein)	NP_444253	NP_647461
Location (UCSC)	Chr 3: 123.61 – 123.88 Mb	Chr 16: 34.75 – 35 Mb
PubMed search	[1]	[2]

Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is encoded by the MYLK gene.

Function

This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.

See also

• Myosin light-chain kinase

External links

• MYLK protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.