Keratin 4
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| Keratin 4, type II | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | KRT4 ; CK-4; CK4; CYK4; K4; WSN1 | ||||||||||||
| External IDs | OMIM: 123940 MGI: 96701 HomoloGene: 20523 GeneCards: KRT4 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 3851 | 16682 | |||||||||||
| Ensembl | ENSG00000170477 | ENSMUSG00000059668 | |||||||||||
| UniProt | P19013 | P07744 | |||||||||||
| RefSeq (mRNA) | NM_002272 | NM_008475 | |||||||||||
| RefSeq (protein) | NP_002263 | NP_032501 | |||||||||||
| Location (UCSC) | Chr 12: 52.81 – 52.81 Mb |
Chr 15: 101.92 – 101.92 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Keratin, type I cytoskeletal 4 also known as cytokeratin-4 (CK-4) or keratin-4 (K4) is a protein that in humans is encoded by the KRT4 gene.[1][2]
Keratin 4 is a type II cytokeratins. It is specifically found in differentiated layers of the mucosal and esophageal epithelia together with keratin 13. Mutations in the genes encoding this protein have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia.[3]
References
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