Fluparoxan
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Systematic (IUPAC) name | |
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(3aS,9aS)-5-fluoro-2,3,3a,9a-tetrahydro-1H-[1,4]benzodioxino[2,3-c]pyrrole
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Clinical data | |
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Routes of administration |
Oral |
Identifiers | |
CAS Number | 105182-45-4 111793-41-0 (hydrochloride) |
ATC code | none |
PubChem | CID: 72036 |
IUPHAR/BPS | 41 |
ChemSpider | 65029 |
UNII | WGA8E072GX Y |
ChEMBL | CHEMBL1765294 |
Chemical data | |
Formula | C10H10FNO2 |
Molecular mass | 195.19 g/mol |
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Fluparoxan (GR-50,360) is a potent and highly selective α2-adrenergic receptor antagonist which was being investigated as an antidepressant but failed to show sufficiently significant efficacy for depression in clinical trials and never made it to the market.[1][2] In animal and/or human studies fluparoxan has been found to produce stimulation, tachycardia, hypertension, hyperthermia, penile erection, and pro-nociceptive effects, as well as antidepressant-like effects, panic, and anxiogenesis.[1][2][3][4]
See also
References
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