Fluparoxan

From Infogalactic: the planetary knowledge core
Jump to: navigation, search
Fluparoxan
Fluparoxan.png
Systematic (IUPAC) name
(3aS,9aS)-5-fluoro-2,3,3a,9a-tetrahydro-1H-[1,4]benzodioxino[2,3-c]pyrrole
Clinical data
Legal status
  • Uncontrolled
Routes of
administration
Oral
Identifiers
CAS Number 105182-45-4 111793-41-0 (hydrochloride)
ATC code none
PubChem CID: 72036
IUPHAR/BPS 41
ChemSpider 65029
UNII WGA8E072GX YesY
ChEMBL CHEMBL1765294
Chemical data
Formula C10H10FNO2
Molecular mass 195.19 g/mol
  • Fc2c1O[C@@H]3[C@@H](Oc1ccc2)CNC3

Fluparoxan (GR-50,360) is a potent and highly selective α2-adrenergic receptor antagonist which was being investigated as an antidepressant but failed to show sufficiently significant efficacy for depression in clinical trials and never made it to the market.[1][2] In animal and/or human studies fluparoxan has been found to produce stimulation, tachycardia, hypertension, hyperthermia, penile erection, and pro-nociceptive effects, as well as antidepressant-like effects, panic, and anxiogenesis.[1][2][3][4]

See also

References

<templatestyles src="Reflist/styles.css" />

Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />
  1. 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
  2. 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.
  3. Lua error in package.lua at line 80: module 'strict' not found.
  4. Lua error in package.lua at line 80: module 'strict' not found.