Oxidopamine

Oxidopamine

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Names
IUPAC name 5-(2-Aminoethyl)benzene-1,2,4-triol
Identifiers
CAS Number	1199-18-4 Y
ChEBI	CHEBI:78741 N
ChEMBL	ChEMBL337702 Y
ChemSpider	4463 Y
Jmol 3D model	Interactive image
KEGG	D05294 Y
PubChem	4624
UNII	8HW4YBZ748 N
InChI InChI=1S/C8H11NO3/c9-2-1-5-3-7(11)8(12)4-6(5)10/h3-4,10-12H,1-2,9H2 Y Key: DIVDFFZHCJEHGG-UHFFFAOYSA-N Y InChI=1/C8H11NO3/c9-2-1-5-3-7(11)8(12)4-6(5)10/h3-4,10-12H,1-2,9H2 Key: DIVDFFZHCJEHGG-UHFFFAOYAG
SMILES c1c(c(cc(c1O)O)O)CCN
Properties
Chemical formula	C8H11NO3
Molar mass	169.18 g/mol
Vapor pressure	{{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Oxidopamine, also known as 6-hydroxydopamine (6-OHDA) or 2,4,5-trihydroxyphenethylamine, is a neurotoxic synthetic organic compound used by researchers to selectively destroy dopaminergic and noradrenergic neurons in the brain. 6-OHDA is thought to enter the neurons via the dopamine and noradrenaline (norepinephrine) reuptake transporters. Oxidopamine is often used in conjunction with a selective noradrenaline reuptake inhibitor (such as desipramine) to selectively destroy dopaminergic neurons.

The main use for oxidopamine in scientific research is to induce Parkinsonism in laboratory animals such as mice, rats and monkeys, in order to develop and test new medicines and treatments for Parkinson's disease. In order to induce this condition in animals, around 70% of the dopaminergic neurons in the substantia nigra of the brain must be destroyed, and this is achieved either with oxidopamine or MPTP. Both these agents likely destroy neurons by generating reactive oxygen species such as superoxide radical. Oxidopamine toxicity in neonatal rodents is also used as an animal model for the Lesch-Nyhan syndrome.

See also

• 5,7-Dihydroxytryptamine
• DSP-4
• MPTP
• Norsalsolinol
• Rotenone