Amfecloral

Amfecloral

Systematic (IUPAC) name
2,2,2-trichloro-N-(1-phenylpropan-2-yl)ethanimine
Clinical data
Legal status	?
Identifiers
CAS Number	5581-35-1 Y
ATC code	none
PubChem	CID: 21759
ChemSpider	20451 Y
UNII	6015XOA0BI Y
KEGG	D02926 Y
ChEMBL	CHEMBL2105544 N
Synonyms	alpha-methyl-N-(2,2,2-trichloroethylidene)phenethylamine; N-(2,2,2-trichloroethylidene)amphetamine
Chemical data
Formula	C11H12Cl3N
Molecular mass	264.58 g/mol
SMILES ClC(Cl)(Cl)/C=N/C(Cc1ccccc1)C
InChI InChI=1S/C11H12Cl3N/c1-9(15-8-11(12,13)14)7-10-5-3-2-4-6-10/h2-6,8-9H,7H2,1H3/b15-8+ Y Key:VBZDETYCYXPOAK-OVCLIPMQSA-N Y
NY (what is this?)  (verify)

Amfecloral (INN), also known as amphecloral (USAN), is a stimulant drug of the phenethylamine and amphetamine chemical classes that was used as an appetite suppressant under the trade name Acutran, but is now no longer marketed. It acts as a prodrug which splits to form amphetamine and chloral hydrate, similarly to clobenzorex and related compounds, except that the N-substituent in this case yields a compound that is active in its own right. The chloral hydrate metabolite is a gabaminergic sedative/hypnotic, and would in theory counteract some of the stimulant effects of the amphetamine metabolite. This would produce an effect similar to the amphetamine/barbiturate combinations previously used in psychiatric medications. Amfecloral can be prepared by the reaction of amphetamine with chloral hydrate.

See also

• Amphetaminil
• Amphetamine
• Clobenzorex
• Desbutal