KCNC3

Potassium channel, voltage gated Shaw related subfamily C, member 3
Identifiers
Symbols	KCNC3 ; KSHIIID; KV3.3; SCA13
External IDs	OMIM: 176264 MGI: 96669 HomoloGene: 3650 IUPHAR: 550 GeneCards: KCNC3 Gene
Gene ontology Molecular function • voltage-gated potassium channel activity • delayed rectifier potassium channel activity Cellular component • plasma membrane • voltage-gated potassium channel complex • integral component of membrane • axolemma • neuromuscular junction • dendrite membrane • neuronal cell body membrane • axon terminus Biological process • potassium ion transport • synaptic transmission • regulation of ion transmembrane transport • regulation of neurotransmitter secretion • protein homooligomerization • potassium ion transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3748	16504
Ensembl	ENSG00000131398	ENSMUSG00000062785
UniProt	Q14003	Q63959
RefSeq (mRNA)	NM_004977	NM_001290682
RefSeq (protein)	NP_004968	NP_001277611
Location (UCSC)	Chr 19: 50.31 – 50.33 Mb	Chr 7: 44.59 – 44.6 Mb
PubMed search	[1]	[2]

Potassium voltage-gated channel, Shaw-related subfamily, member 3 also known as KCNC3 or K_v3.3 is a protein that in humans is encoded by the KCNC3.

Function

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and comprises four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes.

Clinical significance

KCNC3 is associated with spinocerebellar ataxia type 13.

See also

• Voltage-gated potassium channel

External links

• GeneReviews/NCBI/NIH/UW entry on Spinocerebellar Ataxia Type 13

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.