Plomestane

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Plomestane
File:Plomestane.svg
Systematic (IUPAC) name
10H-(2-propynyl)-estr-4-ene-3,17-dione
Identifiers
CAS Number 77016-85-4
ATC code None
PubChem CID: 9904788
ChemSpider 8080442
Chemical data
Formula C21H26O2
Molecular mass 310.430 g/mol
  • O=C4\C=C3/[C@@](CC#C)([C@H]2CC[C@@]1(C(=O)CC[C@H]1[C@@H]2CC3)C)CC4
  • InChI=1S/C21H26O2/c1-3-10-21-12-8-15(22)13-14(21)4-5-16-17-6-7-19(23)20(17,2)11-9-18(16)21/h1,13,16-18H,4-12H2,2H3/t16-,17-,18-,20-,21-/m0/s1
  • Key:JKPDEYAOCSQBSZ-OEUJLIAZSA-N

Plomestane (INN, USAN; MDL-18,962), also referred to as propargylestrenedione (PED), is a steroidal, irreversible aromatase inhibitor which was under development by Marion Merrell Dow/Hoechst Marion Russell (now Hoechst AG) as an antineoplastic agent for the treatment of breast cancer.[1][2][3][4][5] It was found to be effective in preclinical studies and was also found to produce few adverse effects in human clinical trials, significantly reducing estrogen levels with a single administration.[5] However, development of the drug for clinical use was halted due to "technical issues" and it was never marketed.[6]

References

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