Relamorelin
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Systematic (IUPAC) name | |
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4-[[(2S)-2-[[(2R)-2-[[(2R)-3-(1-Benzothiophen-3-yl)-2-(piperidine-3-carbonylamino)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]piperidine-4-carboxamide
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Clinical data | |
Routes of administration |
Subcutaneous |
Identifiers | |
CAS Number | 661472-41-9 |
ATC code | None |
PubChem | CID: 85364156 |
ChemSpider | 32699203 |
Chemical data | |
Formula | C43H50N8O5S |
Molecular mass | 790.9727 g/mol |
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Relamorelin (INN, USAN) (developmental code names RM-131, BIM-28131, BIM-28163) is a synthetic, peptide, centrally penetrant, selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) which is under development by Rhythm Pharmaceuticals for the treatment of diabetic gastroparesis, chronic idiopathic constipation, and anorexia nervosa.[1][2][3] It is a pentapeptide and analogue of ghrelin with improved potency and pharmacokinetics.[1][2] In humans, relamorelin produces increases in plasma growth hormone, prolactin, and cortisol levels,[2][4] and, like other GHSR agonists, increases appetite.[3] As of June 2015, relamorelin is in phase II clinical trials for diabetic gastroparesis and constipation.[5] The United States Food and Drug Administration (FDA) has granted Fast Track designation to relamorelin for diabetic gastroparesis.[6]
See also
- Anamorelin
- Capromorelin
- Examorelin (hexarelin)
- GHRP-6 (SKF-110679)
- Ibutamoren (MK-677)
- Ipamorelin
- Macimorelin
- Pralmorelin (GHRP-2)
- SM-130,686
- Tabimorelin
References
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External links
- Relamorelin (RM-131): Ghrelin Peptide Agonist: A New Drug Class for the Treatment of GI Functional Disorders – Rhythm Pharmaceuticals
- Relamorelin – AdisInsight
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- Amines
- Benzothiophenes
- Carboxamides
- Drugs acting on the gastrointestinal system and metabolism
- Ghrelin receptor agonists
- Growth hormone secretagogues
- Hormonal agents
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- Piperidines
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