Neurotensin receptor

neurotensin receptor 1 (high affinity)
Identifiers
Symbol	NTSR1
Alt. symbols	NTR
Entrez	4923
HUGO	8039
OMIM	162651
RefSeq	NM_002531
UniProt	P30989
Other data
Locus	Chr. 20 q13-20q13

neurotensin receptor 2
Identifiers
Symbol	NTSR2
Alt. symbols	NTR2
Entrez	23620
HUGO	8040
OMIM	605538
RefSeq	NM_012344
UniProt	O95665
Other data
Locus	Chr. 2 p25.1

sortilin 1
Identifiers
Symbol	SORT1
Alt. symbols	Gp95, NT3
Entrez	6272
HUGO	11186
OMIM	602458
RefSeq	NM_002959
UniProt	Q99523
Other data
Locus	Chr. 1 p21.3-1p13.1

The neurotensin receptors are transmembrane receptors that bind the neurotransmitter neurotensin. Two of the receptors encoded by the NTSR1 and NTSR2 genes contain seven transmembrane helices and are G protein coupled. The third receptor has a single transmembrane domain and is encoded by the SORT1 gene.

Ligands

Agonists

Peptide

• Beta-lactotensin (NTS₂)
• JMV-449
• Neurotensin
• Neuromedin N (NTS₁ selective)
• PD-149,163 (NTS₁ selective, reduced amide bond 8-13 fragment of neurotensin)

Non-peptide

• Partial agonists derived from SR-48692

Antagonists

• Levocabastine (NTS₂ selective, also H₁ histamine antagonist)
• SR-48692 (NTS₁ selective)
• SR-142,948 (unselective, CAS# 184162-64-9)

Biophysical Investigation

Unusually for GPCRs, NTS1 can be expressed in an active form in the bacteria E. coli. It can be purified and analysed in vitro and has been analysed by a number of biophysical techniques such as surface plasmon resonance, FRET and cryo-electron microscopy.

External links

• Neurotensin Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)